The analysis of complex and massive datasets and the development of sophisticated computational models are essential to our understanding and prediction of complex phenomena and systems associated with personalized medicine, healthcare delivery, transportation systems, social networks, the human brain, global climate, and international economic development. The Institute for Data, Intelligent Systems, and Computation (I-DISC) builds upon the foundation of Lehigh research expertise in areas such as machine learning, optimization, probabilistic modeling, data-driven decision making, high-performance and data-intensive computing, statistical signal and image processing, data representation and management, modeling and simulation, robotics and computer vision, business and management technology, and privacy and security. Teams of researchers will combine fundamental data and computational approaches with those focused on critical applications, utilizing core high-performance computing and cyber–physical systems facilities. I-DISC will create a fertile space for collaboration with industrial, academic, and governmental partners to attack some of the most pressing problems in technology and society.