Mooi Choo Chuah pursues research in autonomous systems, cloud/edge computing, network and cyber physical system security, healthcare and computer vision. In particular, she maintains active research in efficient computer/mobile vision, perception systems for autonomous vehicles,  mobile healthcare, healthcare data mining, and resilient Smart Grid control networks. She has been awarded some 63 U.S. patents and 15 international patents on topics related to IP QoS, future & 3G wireless system design, resource management, and mobility management.

She is also the associate chair of Lehigh's Computer Science & Engineering Department, and served as one of Lehigh's NSF Advance Chairs for 2011. She is an IEEE fellow and NAI fellow. Before joining Lehigh University, Mooi was a technical manager with Bell Laboratories' Advanced Communications Technology Center, where she worked on wireless communications, IP/MPLS protocol designs and other key contributions.